If your perimenopause symptoms feel heavier, stranger, or more relentless than what the women around you are going through, it might be your DNA.

Listen in as Kim Ressler, Founder and CEO of SNiP Nutrigenomics, and I come together to explore this question: what if your genetic blueprint is shaping not just when you enter menopause, but exactly how hard the whole thing hits you?

If your sex drive has gone quiet and you're chalking it up to just your hormones, sex therapist Brooke Bralove wants you to think again. In this conversation, Brooke breaks down many other reasons midlife women lose desire including resentment, exhaustion, mental overload, and unresolved trauma, and what actually helps bring it back.

If you've looked around at your life lately and thought, I have everything I wanted, so why don't I feel like myself? this episode is for you. I'm joined by Ellen Baker, novelist and founder of The Next Chapter Studio, to talk about reinventing yourself in midlife by doing something most of us have completely backwards: choosing your identity before you have proof you're there.

Are you one of the bajillion women wondering if creatine is something you should be taking? Dr. Miranda Naylor, functional medicine doctor and host of the Modern Women's Wellness podcast, makes the case that creatine is not a gym supplement. It is a women's health supplement, and most of us in midlife are not getting enough.

If you've ever typed a very specific, very personal question into ChatGPT and gotten back an answer that was technically accurate but somehow not quite for you, there's a reason. In this episode, I sit down with Stephanie Georges, a former Wall Street analyst and C-suite executive who is building an AI platform trained specifically on women-informed, evidence-based research.

Alexis Lynch reads more books in a year than most people read in a decade, and in this episode, she brings her full 2026 summer reading list for women over 40. We discuss three picks, updated tips for actually reading more when life is full, and a deep-dive conversation about Heart the Lover by Lily King that is so good we can hardly stand it.

If you have looked in the mirror lately and felt like you're not quite seeing yourself anymore, and you have tried the serums, the fillers, the tightening treatments, this episode is for you. I sat down with Dr. Carolyn Chang, a board-certified plastic surgeon in San Francisco, to answer the question a lot of midlife women are wondering: is there actually something I can do about this? And if so, what exactly is that?

If you've pulled your hair back into a ponytail and thought, my god, where did my hair go, you're in the right place. Hair thinning is one of the most common and least talked-about changes midlife women experience. And it hits harder than people expect, because it isn't just about the hair.

Blood flow restriction training might be the most effective workout method midlife women aren't using yet. If you've been told to lift heavy to maintain muscle after 40, but lifting heavy feels hard on your joints, exhausting, or just completely unrealistic right now, this is worth your attention.

If you have tried more diets than you can count and they all stopped working, or never worked to begin with, you are not the problem. Lizzie Merritt, a certified life coach and bestselling author of LIGHT: The New Psychology of Weight Loss, is here to talk about what is actually going on when traditional diets fail midlife women, why your nervous system has more to do with your eating habits than your willpower does, and what a brain-based approach to weight loss looks like in real life.

If your skin feels completely different than it did a decade ago, drier, more sensitive, and harder to please despite a longer and more expensive routine, you are not imagining it. In this episode of Midlife Advice, I sit down with May Lindstrom, founder of May Lindstrom Skin, to talk about what midlife skin actually needs, why adding more products often backfires, and the simple shifts that make a real difference for women over 40.

Not feeling heard in a relationship is one of the most common challenges for midlife women, especially in long-term partnerships where conversations can start to feel like logistics, criticism, or defensiveness instead of real connection. If you’ve ever wondered why communication in your relationship feels harder than it used to, or why you and your partner keep having the same conversations without actually feeling understood, you’re in the right place.

If you are dealing with brain fog, fatigue, mood swings, irritability, low energy, or a metabolism that feels like it has changed overnight, you might assume hormones are the whole story. And yes, hormones matter. But in this episode, we look at another foundational piece of midlife health that almost no one is talking about enough: mineral imbalances.

Ever catch yourself thinking… why does work feel so hard lately?

You’re showing up, doing everything “right,” and yet you feel more exhausted, more disconnected, and less motivated than ever. If you’ve been wondering if your job is even right for you anymore—or if you’re dealing with career burnout, overwork, or that nagging sense that something is off—this episode is for you.

Most women assume menopause is a fixed point in time—something dictated by genetics that we just have to ride out. But emerging research around ovarian aging is starting to challenge that idea.

What if creating a calmer home didn’t require a full weekend of organizing?

In this conversation, Jessica talks with organizing coach Tracy Hoth about a surprisingly simple approach: a 15-minute daily decluttering habit that helps busy women make real progress without burnout.

If your midlife marriage feels more like roommates than romance, you’re not alone. In this episode, I’m talking with marriage and family therapist Dr. Becky Whetstone about why so many women reconsider their long-term marriage in midlife and what to do when you start thinking, “I think I want out.”

Feeling stuck at Director level despite years of experience and strong performance? Executive coach Katy McFee explains why high-performing midlife women often get passed over for promotion and the simple shifts that can finally get you seen as VP material.

Is your midlife skin looking OLD? Is your hair shedding more than it used to? In this episode, we explore how peptides may support midlife skin, hair loss, inflammation, and longevity.

Are peptides the missing link for midlife women who are doing all the right things and still feel stuck?

If your nutrition, exercise, and sleep are pretty dialed in but you’re still dealing with low-grade fatigue, slower workout recovery, brain fog or stubborn weight gain in perimenopause, this episode is for you.